Bexarotene Plus Erlotinib Suppress Lung Carcinogenesis Independent of KRAS Mutations in Two Clinical Trials and Transgenic Models
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چکیده
منابع مشابه
Bexarotene plus erlotinib suppress lung carcinogenesis independent of KRAS mutations in two clinical trials and transgenic models.
The rexinoid bexarotene represses cyclin D1 by causing its proteasomal degradation. The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) erlotinib represses cyclin D1 via different mechanisms. We conducted a preclinical study and 2 clinical/translational trials (a window-of-opportunity and phase II) of bexarotene plus erlotinib. The combination repressed growth and cyclin...
متن کاملDurable responses to Erlotinib despite KRAS mutations in two patients with metastatic lung adenocarcinoma.
KRAS mutations code for abnormally activated Kras proteins that result in an autonomal activation of its downstream effectors. They account for 10%–30% of lung cancers (Table 1), mainly in adenocarcinoma, and have been linked with smoking history. KRAS mutations have been associated with lack of responsiveness to anti-epidermal growth factor receptor (EGFR) antibodies in colorectal cancer. Cons...
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Lung cancer has limited effective therapy and no effective prevention. Cytotoxic chemotherapy has not improved when combined with the epidermal growth factor receptor (EGFR) inhibitor erlotinib (standard lung cancer therapy) or with the rexinoid bexarotene. Combining erlotinib and bexarotene, however, to cotarget cyclin D1 via the retinoid X receptor and EGFR was active preclinically in KRAS-dr...
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BACKGROUND Somatic mutations in the gene for the epidermal growth factor receptor (EGFR) are found in adenocarcinomas of the lung and are associated with sensitivity to the kinase inhibitors gefitinib (Iressa) and erlotinib (Tarceva). Lung adenocarcinomas also harbor activating mutations in the downstream GTPase, KRAS, and mutations in EGFR and KRAS appear to be mutually exclusive. METHODS AN...
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Background: Safe and effective weight control strategies are needed to stem the current obesity epidemic. The objective of this one-year study was to document and compare the macronutrient and micronutrient levels in the foods chosen by women following two different weight reduction interventions. Methods: Ninety-six generally healthy overweight or obese women (ages 25–50 years; BMI 25– 35 kg/m...
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ژورنال
عنوان ژورنال: Cancer Prevention Research
سال: 2011
ISSN: 1940-6207,1940-6215
DOI: 10.1158/1940-6207.capr-10-0376